RESEARCH

Research projects relating to bioinformatics, computational biology and biomedical engineering

N.Manoj

http://www.biotech.iitm.ac.in/Manoj

1) Protein structure and function and structural bioinformatics of industrially important hydrolases including esterases and glycosidases.
2) Comparative genomics analysis of G-protein coupled receptors (GPCR) and the GPCR signaling pathways.

V.Srinivas Chakravarthy

http://www.biotech.iitm.ac.in/Srinivas

1) Development of a computational model of basal ganglia for Parkinson’s disease.
2) Cardiac Memory involving modeling conduction system of the heart that incorporates dynamic gap junctions.

Sanjib Senapati

http://www.biotech.iitm.ac.in/Sanjib

1) Computational Biophysics including molecular modeling of enzyme-substrate/enzyme-inhibitor interactions, structure-based drug discovery and bio-molecular simulations.
2) Computational Green Chemistry including designing fluorine-based surfactants that stabilize the aqueous proteins in supercritical CO2.

 K.B. Ramachandran

http://www.biotech.iitm.ac.in/KBR

1) Bioreactor Modeling and simulation and control including modeling of immobilized enzyme membrane bioreactors and metabolic flux analysis of Hyaluronic acid

Guhan Jayaraman

http://www.biotech.iitm.ac.in/Guhan

1) Systems level modeling of the cellular stress response to recombinant protein over-expression in Escherichia coli.       

Mukesh Doble

http://www.biotech.iitm.ac.in/Doble

1) Quantitative structure activity relationship (QSAR) for antimicrobial and anti-inflammatory compounds.

Rajamanickam Murugan

http://www.biotech.iitm.ac.in/Murugan